Oxycodone/Acetaminophen
A to Z Drug Facts
Oxycodone/Acetaminophen |
(OX-ee-KOE-dohn/ass-cet-ah-MEE-noe-fen) |
Percocet |
Tablets: 5 mg oxycodone HCl/325 mg acetaminophen, Tablets: 7.5 mg oxycodone HCl/500 mg acetaminophen, Tablets: 10 mg oxycodone HCl/650 mg acetaminophen, Roxicet, Tablets: 5 mg oxycodone HCl/325 mg acetaminophen, Solution, oral: 5 mg oxycodone HCl/325 mg acetaminophen, Roxicet 5/500, Caplets: 5 mg oxycodone/500 mg acetaminophen, Roxilox, Capsules: 5 mg oxycodone HCl/500 mg acetaminophen, Tylox, Capsules: 5 mg oxycodone HCl/500 mg acetaminophen, Endocet, Oxycocet, Percocet-Demi |
Class: Narcotic analgesic combination |
Action Acetaminophen inhibits synthesis of prostaglandins and peripherally blocks pain impulse generation, whereas, oxycodone binds to opiate receptors in CNS. Combination has synergistic effect on alleviating pain.
Indications Relief of moderate-to-moderately severe pain.
Contraindications Hypersensitivity to acetaminophen, oxycodone or similar compounds.
ADULTS: PO 5 mg (1 tablet, caplet, or teaspoonful) q 6 hr prn.
Anesthetics: Additive CNS depression.
Carbamazepine, hydantoins, sulfinpyrazone: Increased risk of hepatotoxicity.
CNS depressants (eg, barbiturates, tricyclic antidepressants, phenothiazines, sedatives, hypnotics, alcohol, other narcotics): Additive CNS depression.
Lab Test Interferences With Chemstrip bG, Dextrostix, and Visidex II home blood glucose systems, may cause false decrease in mean glucose values.
CARDIOVASCULAR: Hypotension; bradycardia; tachycardia. CNS: Lightheadedness; dizziness; weakness; fatigue; sedation; euphoria; dysphoria; nervousness; headache; confusion. DERMATOLOGIC: Pruritus; rash. GI: Nausea; vomiting; constipation; abdominal pain; anorexia; biliary spasm; dry mouth. GU: Urinary retention or hesitancy. RESPIRATORY: Dyspnea; respiratory depression. OTHER: Malaise; tolerance; psychological and physical dependence with chronic use.
Pregnancy: Category C. Lactation: Undetermined. Children: Safety and efficacy not established. Special Risk Patients: Use with caution in elderly, debilitated patients and those with hepatic or kidney failure or conditions accompanied by hypoxia or hypercapnia; monitor carefully to avoid decrease in pulmonary ventilation. Also use cautiously in patients sensitive to CNS depressants, postoperatively and in patients with pulmonary disease. Acute Abdominal Conditions: Diagnosis may be obscured; use with caution. Dependence: Can produce drug dependence; has abuse potential. Head Injury: Respiratory depression and elevation of CSF pressure may be exacerbated. Hepatic Impairment: Chronic alcoholics should limit acetaminophen intake to < 2 g/day. Sulfite Sensitivity: Use with caution in patients known to be sensitive, as some products contain bisulfites.
PATIENT CARE CONSIDERATIONS |
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Copyright © 2003 Facts and Comparisons
David S. Tatro
A to Z Drug Facts