Oxycodone/Acetaminophen

A to Z Drug Facts

Oxycodone/Acetaminophen

 Action
 Indications
 Contraindications
 Route/Dosage
 Interactions
 Lab Test Interferences
 Adverse Reactions
 Precautions
Patient Care Considerations
 Administration/Storage
 Assessment/Interventions
 Patient/Family Education


(OX-ee-KOE-dohn/ass-cet-ah-MEE-noe-fen)
Percocet
Tablets: 5 mg oxycodone HCl/325 mg acetaminophen, Tablets: 7.5 mg oxycodone HCl/500 mg acetaminophen, Tablets: 10 mg oxycodone HCl/650 mg acetaminophen, Roxicet, Tablets: 5 mg oxycodone HCl/325 mg acetaminophen, Solution, oral: 5 mg oxycodone HCl/325 mg acetaminophen, Roxicet 5/500, Caplets: 5 mg oxycodone/500 mg acetaminophen, Roxilox, Capsules: 5 mg oxycodone HCl/500 mg acetaminophen, Tylox, Capsules: 5 mg oxycodone HCl/500 mg acetaminophen, Endocet, Oxycocet, Percocet-Demi
Class: Narcotic analgesic combination

 Action Acetaminophen inhibits synthesis of prostaglandins and peripherally blocks pain impulse generation, whereas, oxycodone binds to opiate receptors in CNS. Combination has synergistic effect on alleviating pain.

 Indications Relief of moderate-to-moderately severe pain.

 Contraindications Hypersensitivity to acetaminophen, oxycodone or similar compounds.

 Route/Dosage

ADULTS: PO 5 mg (1 tablet, caplet, or teaspoonful) q 6 hr prn.

 Interactions

Anesthetics: Additive CNS depression.

Carbamazepine, hydantoins, sulfinpyrazone: Increased risk of hepatotoxicity.

CNS depressants (eg, barbiturates, tricyclic antidepressants, phenothiazines, sedatives, hypnotics, alcohol, other narcotics): Additive CNS depression.

 Lab Test Interferences With Chemstrip bG, Dextrostix, and Visidex II home blood glucose systems, may cause false decrease in mean glucose values.

 Adverse Reactions

CARDIOVASCULAR: Hypotension; bradycardia; tachycardia. CNS: Lightheadedness; dizziness; weakness; fatigue; sedation; euphoria; dysphoria; nervousness; headache; confusion. DERMATOLOGIC: Pruritus; rash. GI: Nausea; vomiting; constipation; abdominal pain; anorexia; biliary spasm; dry mouth. GU: Urinary retention or hesitancy. RESPIRATORY: Dyspnea; respiratory depression. OTHER: Malaise; tolerance; psychological and physical dependence with chronic use.

 Precautions

Pregnancy: Category C. Lactation: Undetermined. Children: Safety and efficacy not established. Special Risk Patients: Use with caution in elderly, debilitated patients and those with hepatic or kidney failure or conditions accompanied by hypoxia or hypercapnia; monitor carefully to avoid decrease in pulmonary ventilation. Also use cautiously in patients sensitive to CNS depressants, postoperatively and in patients with pulmonary disease. Acute Abdominal Conditions: Diagnosis may be obscured; use with caution. Dependence: Can produce drug dependence; has abuse potential. Head Injury: Respiratory depression and elevation of CSF pressure may be exacerbated. Hepatic Impairment: Chronic alcoholics should limit acetaminophen intake to < 2 g/day. Sulfite Sensitivity: Use with caution in patients known to be sensitive, as some products contain bisulfites.


PATIENT CARE CONSIDERATIONS


 Administration/Storage

 Assessment/Interventions

OVERDOSAGE: SIGNS & SYMPTOMS
 Miosis, respiratory depression, CNS depression (somnolence progressing to stupor or coma), hepatic damage, circulatory collapse, cardiopulmonary arrest, death

 Patient/Family Education

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Copyright
© 2003 Facts and Comparisons
David S. Tatro
A to Z Drug Facts

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